| 2001 | OCtech develops first five-year strategic plan |
| 2003 | Student and Community Life Center opens |
| 2005-2010 | Project Lead the Way, Mechatronics, Business, CNA/Health Science, Computer Technicology, Criminal Justice, Education added for students interested in transferring to OCtech – centered around career pathways from Department of Education |
| December 2006 | Math and Science Center opens |
| May 10, 2010 | Anne S. Crook Transportation and Logistics Center opens |
| 2012 | Patrick Student Services building dedicated in honor of longtime Area Commissioner Larry W. Patrick |
| Spring 2019 | Nursing and Health Science Building opens |
| July 8, 1980 | Teleconference system with ETV studios featuring “talkback” capabilities initiated |
| July 31, 1980 | Medical Laboratory Technician program accredited |
| Sept. 16, 1981 | dedication of Agricultural/Industrial Buildings |
| August 1982 | Associate Degree Nursing program begins; Word Processing courses begin; Forest Products Technology begins |
| April 7, 1983 | program for displaced workers begins |
| August 5, 1983 | Industrial Maintenance Mechanics diploma program begins |
| Dec. 22, 1984 | college named Innovative Technical Training Resource Center for Electromechanical Maintenance Technology in South Carolina |
| Nov. 16, 1986 | college awarded $2.8 million in state funds for new Health Sciences Building |
| Feb. 25, 1987 | college begins first geriatric nursing program in South Carolina |
| March 20, 1987 | college breaks ground on new Health Sciences Building |
| Aug. 19, 1987 | Electromechanical Maintenance Technology Resource Center opens |
| Nov. 2, 1987 | Rudy Groomes named Outstanding President for 1987 by the South Carolina Association for Higher Continuing Education |
| Nov. 5, 1987 | first centralized job placement office established |
| September 1988 | Health Sciences Building opens |
| 1992-1993 | Triple C – College Credit Courses – for transfer credit only begin at Edisto High School; first courses were English 101/102 and Math 110/111 |
| January 1993 | OCtech dedicates buildings to three Area Commission charter members: Industrial/Technology, Business/Computer Technology and Faculty Administration buildings to Joe K. Fairey II, John O. Wesner and Ben R. Wetenhall, respectively |
| 1998 | OCtech begins offering online courses |
| February 1971 | Orangeburg-Calhoun Technical basketball team plays first game |
| July 21, 1972 | Clemson University announces acceptance of transfer credit from Orangeburg-Calhoun Technical courses |
| Aug. 11, 1972 | Orangeburg-Calhoun Technical credits become transferable to the University of South Carolina |
| May 11, 1973 | Tool, Die Making program approved |
| Oct. 21, 1973 | Medical Technology curriculum added |
| March 14, 1974 | Phi Theta Kappa Honor Society chartered (for students in degree programs) |
| May 8, 1974 | Orangeburg-Calhoun Technical Education Center becomes Orangeburg-Calhoun Technical College |
| April 9, 1975 | dedication of $2,000,000 college expansion and opening of the Learning Resource Center and Administration Building |
| May 26, 1978 | the Gressette Learning Resource Center and Williams Administration Building dedicated in honor of Sen. L. Marion Gressette of St. Matthews and Sen. Marshall B. Williams of Orangeburg |
| May 26, 1978–April 12, 1979 | Radiologic Technology program accredited |
| May 15, 1961 | Gov. Ernest F. Hollings signs legislation creating the technical education system |
| May 1966 | Legislation passed to create the Orangeburg-Calhoun Area Commission for Technical Education |
| Oct. 12, 1966 | Orangeburg-Calhoun Technical Education Center formally approved by state committee for technical education |
| Oct. 25, 1967 | groundbreaking for Orangeburg-Calhoun Technical Education Center |
| Sept. 16, 1968 | first students registered for courses |
| May 16, 1969 | official dedication ceremony held for Orangeburg-Calhoun Technical Education Center |
| Aug. 18, 1969 | first graduation ceremony held; 30 students awarded diplomas in Air Conditions, Heating and Refrigeration/Automotive Technician/Diesel – Hydraulics Technician/Industrial Electronics/Medical Secretary/Legal Secretary/Welding |